[2-(Trimethylsilyl)ethoxy]methyl acetal (SEM)
Protection :
-
ReagentsTimeYield
-
KH 18-Crown-6 TMS(CH2)2OCH2Cl5 h84 %KH, 18-Crown-6, TMS(CH2)2OCH2ClTHFRT, 5 h, 84%
Deprotection :
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ReagentsTimeYield
-
n-Bu4N+ F-12 h60 %n-Bu4N+ F-HMPA50 °C, 12 h, 60%